However, Arsenal will be without Gilberto and Ashley Cole for the Champions League match against Celta Vigo.
With a comfortable first-leg advantage, Zinedine Zidane rested much of his first team, making 10 changes from the line-up that struggled to a disappointing draw at Celta Vigo on Sunday to fall 16 points behind league leaders Barcelona.
Sevilla and Real Madrid kept the pressure on leaders Barcelona with home wins in the Primera Liga on Sunday.
Tottenham Hotspur, Newcastle United, Blackburn Rovers and Rangers secured four berths for British teams in the knockout phase of the UEFA Cup on Thursday.
A round-up of weekend action in the major European leagues.
Lionel Messi marked his 300th La Liga appearance with a record-equalling hat-trick and an assist for Neymar as Barcelona stayed hard on the heels of leaders Real Madrid with a 5-0 romp at home to Levante on Sunday.
The Brazilian striker scored twice in a 3-2 victory over Celta Vigo in the Champions League first leg knockout tie.
The Arsenal captain is a doubt for the match against Celta Vigo after injuring his knee on Saturday.
Barcelona lost 1-0 at home to Real Zaragoza on a night of upsets in King's Cup quarter-final, first-leg ties on Thursday.
Union Berlin's Paul Jaeckel scored a 76th-minute winner to give his team a 1-0 victory at VfB Stuttgart on Sunday and send them two points clear at the top of the Bundesliga.
The Spanish League leaders slipped to a 2-0 defeat at home to Real Mallorca.
Barca will now visit seventh-placed Osasuna on Saturday before hosting Young Boys in the Champions League next week, when they will look to rebound following a 2-1 loss in their opening match at Monaco.
Real went top with one game to play after thrashing Atletico Madrid 4-0 while rivals Sociedad slipped to a 3-2 defeat at Celta Vigo.
Holders Barcelona were drawn on Friday to play Real Sociedad in the quarter-finals of the King's Cup while Celta Vigo will take on Real Madrid.
Real Madrid's Javier Hernandez struck twice as they came from behind to beat Celta Vigo 4-2 away and keep the pressure on Barcelona at the top of La Liga on Sunday.
An injury to playmaker James Rodriguez could prompt Real Madrid to dip into the transfer market next month and they are interested in Cruzeiro midfielder Lucas Silva among others, coach Carlo Ancelotti said on Monday.
Robert Lewandowski smashed home a rebound to earn Barcelona a 2-1 win against Athletic Bilbao in an absorbing LaLiga clash on Saturday.
Chelsea's Marcos Alonso and Real Madrid's Nacho were notable absentees in defence, along with Atletico Madrid midfielder Koke.
IMAGES from the soccer matches played across leagues on Friday
Barca, with Lionel Messi absent through injury, hit the woodwork on four occasions but luck was not on their side as they lost their second consecutive away game following their 4-1 defeat by Celta Vigo.
La Liga leaders Barcelona were held to a 2-2 home draw by Celta Vigo on Saturday as their former assistant coach Juan Carlos Unzue dented the title hopes of the Catalans, who dropped points for the second game in a row for the first time this campaign.
Holders Barcelona produced a second-half blitz to come from behind and beat Athletic Bilbao 3-1 to book a place in the King's Cup semi-finals after Atletico Madrid crashed out in a shock 3-2 defeat by Celta Vigo.
Chelsea striker Diego Costa has been ruled out of Spain's matches against Macedonia and England through injury, the Spanish football federation said on Thursday. Costa had been struggling to shake off a groin injury he suffered in Chelsea's 5-0 Premier League win over Everton on Saturday and immediately underwent medical tests when he met up with the Spain squad.
Portugal star striker Cristiano Ronaldo, who has been out of action since injuring his knee in the successful Euro 2016 final, has vowed to return soon after stepping up training at Real Madrid's Valdebebas training base.
A summary of Saturday's action in LaLiga, Bundesliga and Serie A.
Spain's Nolito clueless about British referendum moniker
Real Madrid will welcome back the added firepower of talisman Cristiano Ronaldo and striker Karim Benzema when they entertain promoted Osasuna in La Liga on Saturday.
IMAGES from football matches played across Europe on Wednesday.
Real Madrid lost 2-1 at home to Celta Vigo in their Spanish King's Cup quarter-final first leg on Wednesday to slump to their second defeat in a row following a record winning streak.
Barcelona's bid for a fifth La Liga title in six years suffered a surprise setback when the champions crashed to a 1-0 defeat at lowly Real Valladolid on Saturday.
Late Tchouameni header gives Real Madrid 2-1 Las Palmas win and top spot
Kaka wants Real fans to show more gratitude to Cristiano Ronaldo.
